SCI

Introduction: According to the National Spinal Cord Injury Association, as many as 430,It was estimated that 17,000 new SCIs occur in the U.S. Spinal cord injuries can be caused by many factors, such as road accidents (45%), falls from high places (20%), sports injuries (15%), violence (15%), and other activities (5%)  BUT most of these are caused by trauma to the vertebral column, thereby affecting the spinal cord’s ability to send and receive messages from the brain to the body’s systems that control sensory, motor and autonomic function below the level of injury.

According to the Centers for Diseases Control and Prevention (CDC), SCI costs the nation an estimated 10 billion USD each year.

 

. Osteoporosis and spinal tumors can also cause spinal fractures. These conditions account for 80% of spinal fractures in patients between the ages of 18-25 years. As such, males are approximately four times more likely than females to experience spinal fractures.

 

Sign and Symptom: Symptoms will depend on the severity and location of the spinal cord injury. Individuals who present with spinal cord injuries may experience neck pain, back pain, or pain in other affected areas, as well as lack of sensation (numbness), muscle tension, fatigue, and incontinence. Some people can also experience paralysis, which indicates an injury to both the nervous system and spinal cord.  A complete SCI produces total loss of all motor and sensory function below the level of injury. Nearly 50% of all SCIs are complete. Both sides of the body are equally affected. Even with a complete SCI, the spinal cord is rarely cut or transected. More commonly, loss of function is caused by a contusion or bruise to the spinal cord or by compromise of blood flow to the injured part of the spinal cord.

In an incomplete SCI, some function remains below the primary level of the injury. A person with an incomplete injury may be able to move one arm or leg more than the other or may have more functioning on one side of the body than the other.

SCIs are graded according to the American Spinal Injury Association (ASIA) grading scale, which describes the severity of the injury. The scale is graded with letters:

• ASIA A: injury is complete spinal cord injury with no sensory or motor function preserved.
• ASIA B: a sensory incomplete injury with complete motor function loss.
• ASIA C: a motor incomplete injury, where there is some movement, but less than half the muscle groups are anti-gravity (can lift up against the force of gravity with a full range of motion).
• ASIA D: a motor incomplete injury with more than half of the muscle groups are anti-gravity.
• ASIA E: normal.

The more severe the injury, the less likely a recovery will occur.

Spinal concussions can also occur. These can be complete or incomplete, but spinal cord dysfunction is transient, generally resolving within one or two days. Football players are especially susceptible to spinal concussions and spinal cord contusions. The latter may produce neurological symptoms, including numbness, tingling, electric shock-like sensations and burning in the extremities.

Open or penetrating injuries to the spine and spinal cord, especially those caused by firearms, may present somewhat different challenges. Most gunshot wounds to the spine are stable; i.e., they do not carry as much risk of excessive and potentially dangerous motion of the injured parts of the spine. Depending upon the anatomy of the injury, the patient may need to be immobilized with a collar or brace for several weeks or months so that the parts of the spine fractured by the bullet heals. In most cases, surgery to remove the bullet does not yield much benefit and may create additional risks, including infection, cerebrospinal fluid leak and bleeding. However, occasional cases of gunshot wounds to the spine may require surgical decompression and/or fusion in an attempt to optimize outcome.

 

Diagnosis

Patients who have been involved in serious accidents, and present with the symptoms listed above, will need to be cautious with their range of movement, and will also require extra physical support such as wearing a back brace. After conducting a comprehensive physical examination of the patient, the doctor will issue a suitable diagnosis and treatment plan, such as a CT or MRI scan. An MRI scan is usually required in cases of suspected nervous system or spinal cord injury.

 

Treatment: Treatment of SCI begins before the patient is admitted to the hospital. Paramedics or other emergency medical services personnel carefully immobilize the entire spine at the scene of the accident. In the emergency department, this immobilization is continued while more immediate life-threatening problems are identified and addressed. If the patient must undergo emergency surgery because of trauma to the abdomen, chest or another area, immobilization and alignment of the spine are maintained during the operation.

Non-Surgical Treatments

If a patient has a SCI, he or she will usually be admitted to an intensive care unit (ICU). For many injuries of the cervical spine, traction may be indicated to help bring the spine into proper alignment. Standard ICU care, including maintaining a stable blood pressure, monitoring cardiovascular function, ensuring adequate ventilation and lung function and preventing and promptly treating infection and other complications, is essential so that SCI patients can achieve the best possible outcome.

Surgery

Occasionally, a surgeon may wish to take a patient to the operating room immediately if the spinal cord appears to be compressed by a herniated disc, blood clot or other lesion. This is most commonly done for patients with an incomplete SCI or with progressive neurological deterioration. Even if surgery cannot reverse damage to the spinal cord, surgery may be needed to stabilize the spine to prevent future pain or deformity. The surgeon will decide which procedure will provide the greatest benefit to the patient

 

What Makes Our Stem Cell Treatment for Spinal Cord Injury Effective ?

Since 2005, we have been developing comprehensive stem cell treatment for spinal cord injury protocols to overcome the limitations of conventional therapies. In our protocols, stem cells are combined with specialized therapies for spinal cord injury that not only focus on helping the patient to cope with their symptoms, but also treat the root cause of the condition by promoting the healing of the original injury. We believe that our comprehensive stem cell therapy for spinal cord injury gives the best chances of improvements, allowing for a better quality of life. Read more

Optionally and in addition to our stem cell treatment for spinal cord injury protocol, we are providing a cutting edge epidural stimulation technology* that helps neurological signals to bypass the injury site in the spinal cord, helping to regain function below the injury.

What potential improvements after therapy?

The purpose of stem cell therapy is to promote the healing of the original injury in order to restore neurological function. Thus, various kinds of improvement are possible after our treatment and our past patients have experienced the following*:

• Improved motor function
• Increased sensation
• Decreased spasticity
• Decreased neuropathic pain
• Improve bladder & bowel function
• Increase sweating function
• Pain relief

Introduction Spinal muscular atrophy (SMA) is a genetic disease affecting the part of the nervous system that controls voluntary muscle movement.

Most of the nerve cells that control muscles are located in the spinal cord, which accounts for the word spinal in the name of the disease. SMA is muscular because its primary effect is on muscles, which don’t receive signals from these nerve cells. Atrophy is the medical term for getting smaller, which is what generally happens to muscles when they’re not active.

SMA involves the loss of nerve cells called motor neurons in the spinal cord and is classified as a motor neuron disease.

In the most common form of SMA (chromosome 5 SMA, or SMN-related SMA), there is wide variability in age of onset, symptoms and rate of progression. In order to account for these differences, the chromosome 5 SMA often is classified into types 1 through 4.

The age at which SMA symptoms begin roughly correlates with the degree to which motor function is affected: The earlier the age of onset, the greater the impact on motor function. Children who display symptoms at birth or in infancy typically have the lowest level of functioning (type 1). SMA onset in children (types 2 and 3), teens or adults (type 4) generally correlates with increasingly higher levels of motor function.

Chromosome 5 SMA is caused by a deficiency of a motor neuron protein called SMN, for “survival of motor neuron.” This protein, as its name implies, seems to be necessary for normal motor neuron function. Its deficiency is caused by genetic flaws (mutations) on chromosome 5 in a gene called SMN1. Neighboring SMN2 genes can in part compensate for nonfunctional SMN1 genes.

The primary symptom of chromosome 5-related (SMN-related) SMA is weakness of the voluntary muscles. The muscles most affected are those closest to the center of the body, such as those of the shoulders, hips, thighs and upper back. Special complications occur if the muscles used for breathing and swallowing are affected, resulting in abnormalities in these functions. If the muscles of the back weaken, spinal curvatures can develop.

There’s a great deal of variation in the age of onset and level of motor function achieved in chromosome 5-related SMA. These are roughly correlated with how much functional SMN protein is present in the motor neurons, which in turn is correlated with how many SMN2 genes a person has.

Sensory, mental and emotional functioning are entirely normal in chromosome-5 SMA.

Some forms of SMA are not linked to chromosome 5 or SMN deficiency. These forms vary greatly in severity and in the muscles most affected. While most forms, like the chromosome 5-related form, affect mostly the proximal muscles, other forms exist that affect mostly the distal muscles (those farther away from the body’s center) — at least in the beginning.

Causes

SMA types 0, 1, 2, 3 and 4 are inherited as autosomal recessive genetic disorders and are associated with abnormalities (mutations) in the SMN1 and SMA2 genes on chromosome 5 at chromosomal locus 5q11-q13. SMA1 is thought to be the primary disease-causing gene. Approximately 95-98% of affected individuals have deletions in the SMA1 gene and 2-5% have specific mutations in the SMA1 gene that result in a decreased production of the SMN protein. When three or more copies of the SMA2 gene are also present, the disease may be milder.

Genetic diseases are determined by the combination of genes for a particular trait that are on the chromosomes received from the father and the mother.

Recessive genetic disorders occur when an individual inherits the same abnormal gene for the same trait from each parent. If an individual receives one normal gene and one gene for the disease, the person will be a carrier for the disease, but usually will not show symptoms. The risk for two carrier parents to both pass the defective gene and, therefore, have an affected child is 25% with each pregnancy. The risk to have a child who is a carrier like the parents is 50% with each pregnancy. The chance for a child to receive normal genes from both parents and be genetically normal for that particular trait is 25%. The risk is the same for males and females.

Biological or surrogate markers for SMA are under development. These potential surrogate markers studied to date include:

1) Measuring the amount and ratio of full-length and truncated SMN2 RNA transcripts as well as the amount of SMN protein from white blood cells or fibroblast culture.

2) Counting motor units (Motor Unit Number Estimation, or MUNE) which have shown correlation with the SMN2 copy number, age, and function.

3) Quantitative ultrasound in assessing muscle changes in patients with SMA.

4) Electrical impedance myography.

5) The compound action potential determined by EMG in children with SMA. The authors point out that MUNE is difficult and not as reliable as initially thought. A longitudinally study of the surrogate markers will be necessary before any particular one can be used in an intervention study.

 

 

 

Subdivisions of Spinal Muscular Atrophy

• SMA type 0
• SMA type 1
• SMA type 2
• SMA type 3
• SMA type 4

 

 

Sign and Symptoms

SMA type 0 is the most severe form of the disease and is characterized by decreased fetal movement, joint abnormalities, difficulty swallowing and respiratory failure.

SMA type 1 is the most common type of SMA and is also a severe form of the disease. Infants with SMA type 1 experience severe weakness before 6 months of age and never sit independently. Muscle weakness, lack of motor development and poor muscle tone are the major clinical manifestations of SMA type I. Infants with the gravest prognosis have problems sucking or swallowing. Some show abdominal breathing in the first few months of life. Muscle weakness occurs on both sides of the body and the ocular muscles are not affected. A twitching of the tongue is often seen. Intelligence is normal. Most affected children die before two years of age but survival may be dependent on the degree of respiratory function. For more information about SMA type 1, chose “Werdnig Hoffman” disease as your search term in the Rare Disease Database.

The onset of weakness in SMA type 2 patients is usually between 6 and 12 months. Affected children are able to sit independently early in development but are unable to walk even 10 feet independently. A trembling (tremor) of the fingers is almost always seen in SMA type 2. Approximately 70% of those affected do not have deep tendon reflexes. Those affected with SMA type 2 are usually not able to sit independently by the mid-teens or later.

Patients with SMA type 3 (Kugelberg-Welander syndrome) learn to walk but fall frequently and have trouble walking up and down stairs at 2-3 years of age. The legs are more severely affected than the arms. The long-term prognosis depends on the degree of motor function attained as a child. For more information about SMA3 chose “Kugelberg Welander syndrome” as your search term in the Rare Disease Database.

The onset of muscle weakness for those with SMA type 4 is after age 10 years; these patients usually are ambulatory until age 60 years.

Complications of SMA include scoliosis, joint contractures, pneumonia and metabolic abnormalities such as severe metabolic acidosis and dicarboxylic aciduria.

 

Diagnosis

The diagnosis of SMA is suspected when symptoms are present and the diagnosis can be confirmed with molecular genetic testing. Molecular genetic testing is used to determine if a mutation is present in the SMN1 gene. SMA types 0, 1, 2, 3 and 4 are caused by a partial or complete loss of the SMN1 gene and about 95% of those affected will show a deletion of both copies of a specific portion (exon 7 or exon 8) of the gene. About 5% of those affected will show a deletion of exon 7 in one copy of the SMN1 gene and a different mutation in the other copy of the SMN1 gene. Molecular genetic testing can also be used to determine the number of copies of the SMN2 gene.

Prior to the availability of molecular testing, neurophysiologic studies and muscle biopsy were used for diagnosis, but these tests are no longer necessary unless SMN gene testing is normal.

Carrier testing for SMA is available using a molecular genetic test in which the number of copies of the SMN1 gene is determined.

Molecular genetic testing for the VAPB gene is available to diagnose Finkel type SMA.

Care for individuals with SMA is symptomatic and includes physical therapy, occupational therapy, monitoring of respiratory function and nutritional status, orthotics and adaptive equipment. Respiratory support for SMA1 using a breathing machine called BiPAP (bi-level positive airway pressure) has been shown to increase comfort and life expectancy in some affected children.

Genetic counseling is recommended for affected individuals and their families

 

Treatment

The management of children with spinal muscular atrophy starts with the diagnosis and classification into 1 of the 5 categories. Health issues specific to spinal muscular atrophy are as follows:

Pulmonary management: Children with SMA1 can survive beyond 2 years of age when offered tracheostomy or noninvasive respiratory support.

An intermittent positive-pressure breathing device (mechanical in-exsufflator) has proven effective.

Nutrition: Bulbar dysfunction is universal in SMA1 patients. Early gastrostomy should be considered as part of the management of such patients. The bulbar dysfunction eventually becomes a serious problem for spinal muscular atrophy II patients and only very late in the course of disease for spinal muscular atrophy III patients.

Scoliosis: Scoliosis is a major problem in most SMA2 patients and in half of SMA3 patients.

The vertical expandable prosthetic titanium rib (VEPTR) was approved by the FDA in 2004 as a treatment for thoracic insufficiency syndrome (TIS) in pediatric patients. TIS is a congenital condition where severe deformities of the chest, spine, and ribs prevent normal breathing and lung development. The VEPTR is an implanted, expandable device that helps straighten the spine and separate ribs so that the lungs can grow and fill with enough air to breathe. The length of the device can be adjusted as the patient grows. The titanium rib was developed at the University of Texas Health Science Center in San Antonio. It is manufactured by Synthes Spine Co.

Hip dislocation: Hip dislocation is another orthopedic concern in patients with spinal muscular atrophy. If the hip dislocation is asymptomatic, surgery is not indicated.

Behavior issues: Compared to siblings and normal controls, patients with spinal muscular atrophy were quite well adjusted. Concern was, however, raised about unaffected siblings, who had a 2 to 3-fold higher rate behavioral problems than normal children.

Sleep disorders: Sleep-disordered breathing may develop prior to respiratory failure. Night-time use of continuous positive airway pressure with a nasal mask may be helpful.

In 2017, Spinraza (nusinersen) was FDA approved as the first drug to treat children and adults with SMA. Spinraza is manufactured by Biogen.

 

How Functional medicine can help this condition?

 

What Makes our Stem Cell Treatment for SMA Effective?

Since 2005, we have been developing comprehensive protocols regarding stem cell treatment for Spinal Muscular Atrophy (SMA) to overcome the limitations of conventional therapies. In our protocols, stem cells are combined with specialized therapies for spinal muscular atrophy that not only focus on helping the patient to cope with their symptoms, but also treat the direct cause of the symptoms by promoting the healing of the injury in the spinal cord. We believe that our comprehensive stem cell treatment for spinal muscular atrophy gives our patients the best chances of improvements, allowing for a better quality of life. Different types of spinal muscular atrophy can be considered for treatment such as SMA type 1, SMA type 2, SMA type 3 (Kugelberg-Welander syndrome) and more.

What potential improvements after the treatment?

The purpose of our treatment for spinal muscular atrophy is to promote the healing of the injury in the spinal cord in order to restore neurological function. Thus, various kinds of improvement are possible after our treatment and our past patients have experienced the following*:

• Improved range of movements
• Increased muscle mass
• Increased muscle strength
• Better coordination
• Improved balance
• Improved development

Decreased muscle rigidity